Immunohistochemical Study of Scrub Typhus: A Report of Two Cases

Immunohistochemical Study of Scrub Typhus: A Report of Two Cases

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Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi, which is transmitted by chiggers.The target cells of this rickettsia are poorly defined in humans.Immunohistochemical staining of tissue sections of patients with scrub typhus is helpful in investigating the target cells of this rickettsia in different organs.We studied two autopsy knipex 88 01 180 specimens by immunohistochemical staining using a specific antibody against O.

tsutsugamushi.Rickettsiae were located in endothelial cells in all of the organs evaluated, namely heart, lung, brain, kidney, appendix and skin, within cardiac muscle cells and renal tubular epithelial cells, and in macrophages located in the lymph node, liver and spleen.In conclusion, O.tsutsugamushi may disseminate into multiple organs through endothelial cells and macrophages, resulting in the development modular pillow stack of fatal complications.